Universal Platform for Living Adaptive Toxin-removal (UNI-PLAT)

SBIR/STTR topic ARPA-H 03 (U.S. Department of Health and Human Services – ARPA-H), Phase I and II. Open to U.S. small businesses; STTR projects partner with a U.S. research institution. Opens: June 11, 2026. Closes: September 30, 2027. The purpose of this topic area is to catalyze the development of a universal, “plug-and-play” synthetic biology platform that enables next-generation microbial chassis capable of performing a broad array of programmable functions. While this solicitation primarily uses toxin removal as a proof-of-concept in relation to chronic disease management, the platform is intended to be adaptable to a range of challenges across industries such as environmental remediation, biomanufacturing, agriculture, holistic medicine, and therapeutic discovery. The broader goal is to create a stable, reliable, and easily reprogrammable microbial platform that demonstrates potential for cross-sector impact beyond the initial use case. Official solicitation: https://sam.gov/workspace/contract/opp/34fa75da1d484987bd6dbc882deab889/view