Rapid Comprehensive Diagnostic Test for Multi-System Autoimmune Disease

SBIR/STTR topic ARPA-H 06 (U.S. Department of Health and Human Services – ARPA-H), Phase I and II. Open to U.S. small businesses; STTR projects partner with a U.S. research institution. Opens: June 11, 2026. Closes: September 30, 2027. The purpose of this topic is to spur the development of novel, rapid diagnostic assays for multi-system autoimmune disease, which represents an unmet healthcare need. Moreover, in its ideal embodiment this diagnostic test might allow typical primary care physicians to diagnose and predict tissue-specific autoimmune disease manifestations, thereby streamlining referral of the patient to a specialist. This goal is made more feasible by recent technological developments including the ability to detect tissue-specific signatures of immune-mediated stress by assessing circulating cells and/or tissue-specific molecular products. Official solicitation: https://sam.gov/workspace/contract/opp/34fa75da1d484987bd6dbc882deab889/view