Prevention and mitigation of misuse of synthetic biology for bioterrorism purposes

Open EU call topic HORIZON-CL3-2026-01-FCT-06 · HORIZON Research and Innovation Actions. Part of call HORIZON-CL3-2026-01: Civil Security for Society 2026. Next deadline 2026-11-05. Topic page: https://ec.europa.eu/info/funding-tenders/opportunities/portal/screen/opportunities/topic-details/HORIZON-CL3-2026-01-FCT-06

Expected Outcome: Project results are expected to contribute to all of the following expected outcomes: - Increased understanding of European policy makers, research community, biotech companies, and relevant security practitioners of the threat of bioterrorism and of synthetic biology, including a thorough lawful analysis of what needs to be monitored in this context, what needs to be regulated and how; - Awareness raised within the related scientific community how research in synthetic biology can be used for malicious purposes.

Scope: The rising threat of bioterrorism is driven by recent scientific advancements, notably by growing accessibility of synthetic biology, genetic engineering, related commercial services and public databases, which in turn enhance their obtainability to non-state actors and individuals with malicious intentions. The proliferation of do-it-yourself biohacking and community laboratories, including gene editing and sequencing technology, dropping costs of equipment and increased simplicity of use may inadvertently facilitate knowledge and skills dissemination about biological threats and open new pathways for bioterrorism. Challenges in detection, particularly the lengthy incubation periods of biological agents, underscore the urgent need for improved identification technologies to allow for timely intervention and reduce potential mass casualties, considering both characterization through advanced tools by expert labs and simple deployable methods. Given that properly weaponized biological agents can be more lethal than nuclear weapons, their cross-border implications warrant focused attention. Recent incidents involving…