NIH Specialized Center Grant (Parent P50)

Forecasted opportunity (not yet open for applications; expected to be posted around 2026-11-09; estimated application due date 2027-01-11). Through this Notice of Funding Opportunity (NOFO), the participating NIH Institutes, Centers, and Offices (ICOs) encourage pursuit of the NIH’s mission through the submission of investigator-initiated Specialized Center (P50) applications. With this Parent P50 NOFO, the NIH ICOs intend to support a broadly based, multidisciplinary, often long-term research program with a specific major scientific objective or theme. The proposed Specialized Center must be related to the programmatic interests of one or more of the participating ICOs based on their scientific missions. Applications submitted in response to this NOFO are required to include one administrative core, research projects, and at least one resource core. Inclusion of a Pilot Projects core is optional. The research projects included within the Specialized Center must share a common central scientific theme, focus, and/or an overall objective. Emphasis on how the component research projects build on one another to achieve goals beyond the scope of each individual project is also expected. Specialized Center must demonstrate synergy through cohesiveness, shared resources, and collaborative impact. Statutory authority: Awards are made under the authorization of Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.