NIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional)

STTR topic PA-27-102 (U.S. Department of Health and Human Services), Phase I and II. Open to U.S. small businesses; STTR projects partner with a U.S. research institution. Opens: August 5, 2026. Closes: April 6, 2027. Background The Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs (also known as America's Seed Fund) are major sources of early-stage funding for U.S. technology development and commercialization. By providing awards to SBCs that partner with non-profit research institutions, the STTR program supports the commercialization of innovative technologies and strengthens both U.S. small businesses and research communities. The National Institutes of Health (NIH) uses these programs to help US-owned and operated small businesses develop promising technologies and products that support the NIH mission to enhance health, lengthen life, and reduce illness and disability. NIH is required to set aside 0.45% of its extramural research budget for the STTR program. What this NOFO supports This NOFO supports a small business to do the research and development (R&D) needed to develop a commercial product in partnership with a non-profit research institution. STTR projects are required to have a formal collaboration with a nonprofit research institution, such as a university. The Program Director/Principal investigator (PD/PI) may be employed with either the small business or the partnering nonprofit research institution. Regardless of the PD/PI employment, the award is always made to the small business. See eligibility requirements in Section III. For projects that do not depend on such a collaboration, a small business can apply to SBIR NOFO PA-27-100. Applicants are strongly encouraged to contact program staff prior to applying to help choose the best funding opportunity for their project. The STTR Program supports projects through multiple phases: Phase I: Establish the technical merit and feasibility of the…