NIH Director's Transformative Research Award (R01 Clinical Trial Optional)
- Funder
- National Institutes of Health
- Award amount
- Not specified
- Deadline
- September 3, 2027
- Eligible countries
- United States
Summary
Forecasted opportunity (not yet open for applications; expected to be posted around 2027-03-15; estimated application due date 2027-09-03). The NIH Director's Transformative Research Award supports individual scientists and research teams pursuing bold, groundbreaking, and unconventional research with the potential to transform science, create new scientific paradigms, establish new clinical approaches, or develop transformative technologies. The Transformative Research Award is part of the NIH Common Fund's High-Risk, High-Reward Research Program.
Summary as listed on Grants.gov (opportunity 363802). Always read the full announcement for eligibility, limits and how to apply.
Read the full announcement on Grants.gov →This is an NIH R01 call. Read our plain-language guide to the mechanism: who is eligible, typical budgets and how applications are reviewed.
What National Institutes of Health reviewers look for
- Importance of the research (significance and innovation), scored 1–9.
- Rigor and feasibility of the approach, scored 1–9. Preliminary data and alternative strategies carry much of this.
- Expertise and resources, rated sufficient or not, without a score.
- Overall impact: the likelihood the project will have a sustained, powerful influence on its field.
Read our guide: what funded applications do →
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