NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional)

SBIR topic PA-27-100 (U.S. Department of Health and Human Services), Phase I and II. Open to U.S. small businesses. Opens: August 5, 2026. Closes: April 6, 2027. Background The Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs (also known as America's Seed Fund) are major sources of early-stage funding for U.S. technology development and commercialization. By providing awards to SBCs, the SBIR program supports the commercialization of innovative technologies and strengthens U.S. small businesses. The National Institutes of Health (NIH), Centers for Disease Control and Prevention (CDC), and the Food and Drug Administration (FDA) use these programs to help US-owned and operated small businesses develop promising technologies and products that support their missions to enhance the health and well-being of all Americans. NIH, CDC and FDA are required to set-aside 3.2% of their extramural research budget for the SBIR program. What this NOFO supports This NOFO supports a small business to do the research and development (R&D) needed to develop a commercial product. The small business should propose to do the majority of the research or analytical effort, and the Program Director/Principal investigator (PD/PI) should be primarily employed by the small business. SBIR projects allow for limited research or analytical effort to be done by research partners or consultants. See eligibility requirements in Section III. Small businesses should apply to STTR NOFO PA-27-102 if the project depends on a formal collaboration with a nonprofit research institution, such as a university. STTRs also allow the PD/PI of the project to be primarily employed by either the small business or nonprofit research partner. In both the SBIR and STTR programs, the award goes to the small business. Applicants are strongly encouraged to contact program staff prior to applying to help choose the best funding opportunity for their project. The SBIR…