Improving Linkage to Care for People with Opioid Use Disorder (U01)

Forecasted opportunity (not yet open for applications; expected to be posted around 2026-10-01; estimated application due date 2026-12-01). The Centers for Disease Control and Prevention’s (CDC) National Center for Injury Prevention and Control (NCIPC, Injury Center) is soliciting investigator-initiated research to develop, implement, and rigorously evaluate strategies to address and overcome barriers to implementing evidence-based linkage to care services in health care settings. Strategies should focus on individuals with opioid use disorder (OUD) or who meet criteria consistent with an OUD and are at risk of an opioid overdose with or without involvement of other substances. Applicants are expected to have at least one partnership with a public health entity or bona fide agent to identify solutions to challenges in linkages to care. The proposed research should articulate how partnerships with public health entities were established or fostered. All applicants must also propose to collaborate with a local champion in a health care setting to improve linkage to care services and outcomes.Outcomes can be captured by at least two required measures as defined in the NOFO. Solutions are expected to be actionable approaches that can be adopted by clinicians and health systems in real-world settings and ensure availability of comprehensive overdose prevention services.