Digital Health Technology and Reciprocal Innovation to Improve Clinical and Public Health Outcomes

Forecasted opportunity (not yet open for applications; expected to be posted around 2026-12-01; estimated application due date 2027-02-11). This initiative will support research on the development, validation, feasibility, and effectiveness of innovative digital health interventions or tools (including mobile health) specifically suited for underserved settings in the U.S. and globally. Research should utilize new or emerging technologies, platforms, systems, and/or analytics to address high priority health problems, expand the evidence base for the use of digital health technology to improve clinical and public health outcomes, and strengthen research collaborations between U.S. and low- and middle-income country (LMIC) researchers. Applications must include reciprocal innovation methodologies – bidirectional and iterative exchange of ideas, resources, and innovation approaches to address shared health challenges in the U.S. and a LMIC. Through this utilization of unique data, environments, and populations in domestic and international contexts, awards will maximize generalizable knowledge produced and optimize potential benefit to U.S. and LMIC populations.