Collaborate with the functional genomics screening laboratory

Open UKRI funding opportunity · Other. Open with no closing date. Opportunity page: https://www.ukri.org/opportunity/collaborate-with-the-functional-genomics-screening-laboratory/

Apply to collaborate with the functional genomics screening laboratory (FGSL) on projects using complex human in vitro models for CRISPR screening to better understand model biology and enable target identification.

You must be a researcher eligible for MRC funding.

Applications from UK based industry parties may also be considered.

The service from the FGSL is already funded, however cost will be considered when assessing feasibility of the project.

What we're looking for Scope

You will collaborate with the FGSL on projects using complex human in vitro models for CRISPR screening to better understand model biology and enable target identification.

You will define the purpose of the screen and the desired outcomes.

Screens will be carried out by scientists employed at Milner Therapeutics Institute (MTI). However, all screens will be run as collaborations to ensure the best possible outcome and data.

You do not need a CRISPR library as provision has been made for library access as part of a collaboration with AstraZeneca and the MTI. However, for small and medium-sized enterprises and industry, we recommend provision of your own library to avoid a conflict of interest.

For more detailed guidance for this opportunity, please visit Connect: Health Tech at the University of Cambridge.

Duration

Duration will be decided on a case-by-case basis and will depend on:

- the model

- its expansion capacity

- the size of the proposed screen

All projects will be highly collaborative.

Input from the proposing lead applicant will be key to understand:

- the model

- the screen of interest

- likely endpoint assays

Funding available

All screens will be run by scientists employed by MTI and the costs for this are borne by MTI and AstraZeneca.

Financial support for screens (consumables)…