ancient DNA for Modern Genomics (aDMG) Research Projects (U01 Clinical Trials Not Allowed)

Forecasted opportunity (not yet open for applications; expected to be posted around 2027-08-03; estimated application due date 2028-02-01). The National Human Genome Research Institute (NHGRI) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications to establish an ancient DNA for Modern Genomics (aDMG) program. The goal of aDMG is to establish an ethical resource of ancient and historical human DNA (aDNA) data to advance studies about contemporary human traits and biology. This NOFO aims to solicit applications that will leverage existing and newly generated aDNA data from this consortium to advance the biological and epidemiological understanding of modern human diseases and health-related traits by integrating aDNA with modern human and other species’ data. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U01 activity code. Investigators with expertise and insights into this area of ancient DNA and population genomics are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in DNA sequencing methods and technology, computational genomics and data science, human evolution, and ancient human populations will be encouraged and these investigators should also begin considering applying for this application.